cardiovascular disease: A disease involving the cardiovascular system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
229530 |
6. Filter based on genotype QC (FinnGen only) |
221781 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Cardiovascular diseases (excluding rheumatic etc)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2530258 | 1244524 | 1251506 |
| Only index persons | 1816911 | 950250 | 866661 |
| Unadjusted period prevalence (%) | |||
| Whole population | 35.31 | 35.65 | 34.97 |
| Only index persons | 34.05 | 34.93 | 33.08 |
| Median age at first event (years) | |||
| Whole population | 56.91 | 56.69 | 57.04 |
| Only index persons | 54.61 | 54.19 | 55.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 221781 | 107049 | 114732 |
| Unadjusted period prevalence (%) | 50.10 | 42.04 | 57.62 |
| Median age at first event (years) | 53.79 | 51.36 | 56.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FG_CVD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_CVD | 1.331 [1.24, 1.43] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 129640 out of 571235 females with FG_CVD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_CVD | 1.475 [1.37, 1.58] | < 0.001 |
| Birth year | 0.978 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 149905 out of 607111 males with FG_CVD died.
Mortality risk
Mortality risk for people of age
years, who have FG_CVD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.054% | 0.145% |
| 5 | 0.451% | 0.903% |
| 10 | 1.192% | 2.212% |
| 15 | 2.274% | 4.315% |
| 20 | 4.022% | 7.334% |
Relationships between endpoints
↥Index endpoint: FG_CVD – Cardiovascular diseases (excluding rheumatic etc)
GWS hits: 87
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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