vascular disease: A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma.
Diseases of arteries, arterioles and capillaries (FINNGEN)
DOID EFO Endpoint Browser PheWeb
FG_DOAAC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
27526 |
6. Filter based on genotype QC (FinnGen only) |
26613 |
Control definitions (FinnGen only)
Control exclude
FG_CVD
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Diseases of arteries, arterioles and capillaries (FINNGEN)
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 271134 | 104326 | 161965 |
| Only index persons | 175455 | 69098 | 106357 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.94 | 2.99 | 4.53 |
| Only index persons | 3.46 | 2.54 | 4.06 |
| Median age at first event (years) | |||
| Whole population | 71.95 | 76.08 | 69.35 |
| Only index persons | 71.31 | 75.18 | 68.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26613 | 7394 | 19219 |
| Unadjusted period prevalence (%) | 7.78 | 2.90 | 9.65 |
| Median age at first event (years) | 68.99 | 69.24 | 68.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FG_DOAAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_DOAAC | 2.472 [2.25, 2.72] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 35131 out of 63939 females with FG_DOAAC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_DOAAC | 2.466 [2.24, 2.71] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 48080 out of 97729 males with FG_DOAAC died.
Mortality risk
Mortality risk for people of age
years, who have FG_DOAAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | 0.418% |
| 5 | 1.058% | 2.305% |
| 10 | 2.692% | 5.249% |
| 15 | 5.437% | 9.374% |
| 20 | 9.357% | 15.133% |
Relationships between endpoints
↥Index endpoint: FG_DOAAC – Diseases of arteries, arterioles and capillaries (FINNGEN)
GWS hits: 29
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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