atherosclerosis: Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
18443 |
4. Check minimum number of eventsNone |
18443 |
5. Include endpointsNone |
18443 |
6. Filter based on genotype QC (FinnGen only) |
17832 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I70-I79
Name in latin
Atherosclerosis
Similar endpoints
↥List of similar endpoints to
Atherosclerosis, excluding cerebral, coronary and PAD
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 196160 | 81610 | 110955 |
| Only index persons | 123818 | 53401 | 70417 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.79 | 2.34 | 3.10 |
| Only index persons | 2.38 | 1.96 | 2.69 |
| Median age at first event (years) | |||
| Whole population | 72.94 | 77.00 | 70.02 |
| Only index persons | 72.49 | 76.43 | 69.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 17832 | 5422 | 12410 |
| Unadjusted period prevalence (%) | 4.98 | 2.13 | 6.23 |
| Median age at first event (years) | 69.62 | 70.33 | 69.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_ATHSCLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ATHSCLE | 2.431 [2.21, 2.67] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 30539 out of 51689 females with I9_ATHSCLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ATHSCLE | 2.487 [2.26, 2.73] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 38585 out of 68772 males with I9_ATHSCLE died.
Mortality risk
Mortality risk for people of age
years, who have I9_ATHSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.198% | 0.383% |
| 5 | 1.368% | 2.326% |
| 10 | 3.054% | 6.369% |
| 15 | 5.904% | 11.945% |
| 20 | 9.934% | 20.183% |
Relationships between endpoints
↥Index endpoint: I9_ATHSCLE – Atherosclerosis, excluding cerebral, coronary and PAD
GWS hits: 18
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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