aortic aneurysm: A ruptured aneurysm located in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9090 |
4. Check minimum number of eventsNone |
9090 |
5. Include endpoints |
9212 |
6. Filter based on genotype QC (FinnGen only) |
8923 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Aortic aneurysm
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65409 | 13862 | 50372 |
| Only index persons | 46805 | 10214 | 36591 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.19 | 0.40 | 1.41 |
| Only index persons | 1.17 | 0.38 | 1.40 |
| Median age at first event (years) | |||
| Whole population | 70.61 | 73.53 | 69.81 |
| Only index persons | 70.20 | 72.79 | 69.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8923 | 1381 | 7542 |
| Unadjusted period prevalence (%) | 3.29 | 0.54 | 3.79 |
| Median age at first event (years) | 69.74 | 68.91 | 69.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_AORTANEUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTANEUR | 2.075 [1.86, 2.31] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.138 |
During the follow-up period (1.1.1998 — 31.12.2019), 3425 out of 8619 females with I9_AORTANEUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTANEUR | 1.875 [1.7, 2.07] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 12285 out of 31526 males with I9_AORTANEUR died.
Mortality risk
Mortality risk for people of age
years, who have I9_AORTANEUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.2% | 0.327% |
| 5 | 1.128% | 2.28% |
| 10 | 2.89% | 5.629% |
| 15 | 5.666% | 10.523% |
| 20 | 9.526% | 17.455% |
Relationships between endpoints
↥Index endpoint: I9_AORTANEUR – Aortic aneurysm
GWS hits: 24
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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