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Abdominal aortic aneurysm (AAA)

Endpoint Browser PheWeb

I9_ABAORTANEUR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I71.3, I71.4
  • Hospital discharge: ICD-9 — 4413A|4414A
  • Hospital discharge: ICD-8 — 44120
  • Cause of death: ICD-10 — I71.3, I71.4
  • Cause of death: ICD-9 — 4413A|4414A
  • Cause of death: ICD-8 — 44120

2 out of 7 registries used, show all original rules.

4217

4. Check minimum number of events

None

4217

5. Include endpoints

None

4217

6. Filter based on genotype QC (FinnGen only)

4083

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6v3

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34587 5897 27842
Only index persons 21643 3799 17844
Unadjusted period prevalence (%)
Whole population 0.68 0.17 0.78
Only index persons 0.59 0.14 0.68
Median age at first event (years)
Whole population 73.15 77.42 72.28
Only index persons 73.47 77.59 72.59

-FinnGen-

Key figures

All Female Male
Number of individuals 4083 314 3769
Unadjusted period prevalence (%) 1.76 0.12 1.89
Median age at first event (years) 72.32 73.11 72.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_ABAORTANEUR and mortality.

Females

Parameter HR [95% CI] p-value
I9_ABAORTANEUR 2.409 [2.12, 2.74] < 0.001
Birth year 0.997 [0.99, 1.0] 0.437

During the follow-up period (1.1.1998 — 31.12.2019), 2212 out of 3534 females with I9_ABAORTANEUR died.

Males

Parameter HR [95% CI] p-value
I9_ABAORTANEUR 2.188 [1.98, 2.42] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 9519 out of 16651 males with I9_ABAORTANEUR died.

Mortality risk

Mortality risk for people of age

years, who have I9_ABAORTANEUR.

N-year risk Females Males
1 0.288% 0.38%
5 1.454% 2.117%
10 3.478% 5.131%
15 6.728% 9.621%
20 11.65% 16.002%

Relationships between endpoints

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Index endpoint: I9_ABAORTANEUR – Abdominal aortic aneurysm (AAA)

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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