No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4613 |
4. Check minimum number of eventsNone |
4613 |
5. Include endpointsNone |
4613 |
6. Filter based on genotype QC (FinnGen only) |
4460 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Thoracic aortic aneurysm
based on the number of shared cases.
Similar with more cases:
- Aortic aneurysm
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24674 | 6167 | 18370 |
| Only index persons | 22449 | 5504 | 16945 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.18 | 0.51 |
| Only index persons | 0.54 | 0.20 | 0.65 |
| Median age at first event (years) | |||
| Whole population | 68.70 | 71.57 | 67.74 |
| Only index persons | 68.27 | 70.81 | 67.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4460 | 946 | 3514 |
| Unadjusted period prevalence (%) | 1.47 | 0.37 | 1.76 |
| Median age at first event (years) | 68.35 | 68.37 | 68.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_THAORTANEUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THAORTANEUR | 2.039 [1.76, 2.36] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.616 |
During the follow-up period (1.1.1998 — 31.12.2019), 1030 out of 4265 females with I9_THAORTANEUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THAORTANEUR | 1.448 [1.27, 1.65] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2714 out of 13204 males with I9_THAORTANEUR died.
Mortality risk
Mortality risk for people of age
years, who have I9_THAORTANEUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.209% | 0.275% |
| 5 | 1.415% | 1.476% |
| 10 | 3.276% | 3.947% |
| 15 | 6.012% | 7.217% |
| 20 | 10.498% | 12.136% |
Relationships between endpoints
↥Index endpoint: I9_THAORTANEUR – Thoracic aortic aneurysm
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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