No definition available.
Arterial embolism and thrombosis of lower extremity artery
EFO MESH Endpoint Browser PheWeb
I9_ARTEMBTHRLOW
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1206 |
4. Check minimum number of eventsNone |
1206 |
5. Include endpointsNone |
1206 |
6. Filter based on genotype QC (FinnGen only) |
1170 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I74
Name in latin
Embolia arteriarum membrorum inferiorum
Similar endpoints
↥List of similar endpoints to
Arterial embolism and thrombosis of lower extremity artery
based on the number of shared cases.
Similar with more cases:
- Arterial embolism and thrombosis
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15872 | 7887 | 7734 |
| Only index persons | 9951 | 4973 | 4978 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.23 | 0.22 |
| Only index persons | 0.19 | 0.18 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 75.44 | 80.10 | 70.77 |
| Only index persons | 74.25 | 79.43 | 69.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1170 | 448 | 722 |
| Unadjusted period prevalence (%) | 0.29 | 0.18 | 0.36 |
| Median age at first event (years) | 70.21 | 70.44 | 70.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_ARTEMBTHRLOW and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ARTEMBTHRLOW | 2.851 [2.42, 3.37] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.168 |
During the follow-up period (1.1.1998 — 31.12.2019), 2881 out of 4466 females with I9_ARTEMBTHRLOW died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ARTEMBTHRLOW | 2.71 [2.34, 3.13] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 2545 out of 4597 males with I9_ARTEMBTHRLOW died.
Mortality risk
Mortality risk for people of age
years, who have I9_ARTEMBTHRLOW.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.666% |
| 5 | 1.632% | 3.398% |
| 10 | 3.837% | 8.646% |
| 15 | 7.118% | 16.2% |
| 20 | 12.897% | 25.911% |
Relationships between endpoints
↥Index endpoint: I9_ARTEMBTHRLOW – Arterial embolism and thrombosis of lower extremity artery
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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