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Embolism and thrombosis of abdominal aorta

MESH Endpoint Browser PheWeb

I9_EMBTHROAOR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I74.0
  • Hospital discharge: ICD-9 — 4440A
  • Hospital discharge: ICD-8 — 44400
  • Hospital discharge: excluded ICD-10 — 4440
  • Cause of death: ICD-10 — I74.0
  • Cause of death: ICD-9 — 4440A
  • Cause of death: ICD-8 — 44400
  • Cause of death: excluded ICD-10 — 4440

2 out of 7 registries used, show all original rules.

69

4. Check minimum number of events

None

69

5. Include endpoints

None

69

6. Filter based on genotype QC (FinnGen only)

65

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I74
Name in latin Embolia aortae abdominalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1280 501 743
Only index persons 645 296 349
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 69.24 72.62 66.98
Only index persons 67.13 69.55 65.08

-FinnGen-

Key figures

All Female Male
Number of individuals 65 17 48
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 64.72 58.14 67.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint I9_EMBTHROAOR and mortality.

Females

Parameter HR [95% CI] p-value
I9_EMBTHROAOR 2.778 [1.94, 3.97] < 0.001
Birth year 0.998 [0.99, 1.01] 0.623

During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 237 females with I9_EMBTHROAOR died.

Males

Parameter HR [95% CI] p-value
I9_EMBTHROAOR 3.284 [2.2, 4.89] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 178 out of 309 males with I9_EMBTHROAOR died.

Mortality risk

Mortality risk for people of age

years, who have I9_EMBTHROAOR.

N-year risk Females Males
1 0.323% 0.636%
5 1.725% 3.637%
10 4.106% 9.346%
15 8.048% 17.548%
20 15.086% 28.406%

Relationships between endpoints

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Index endpoint: I9_EMBTHROAOR – Embolism and thrombosis of abdominal aorta

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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