heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1871 |
4. Check minimum number of eventsNone |
1871 |
5. Include endpointsNone |
1871 |
6. Filter based on genotype QC (FinnGen only) |
1800 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I70-I79
Name in latin
Alia aneurysmata
Similar endpoints
↥List of similar endpoints to
Other aneurysm
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14108 | 4809 | 9130 |
| Only index persons | 10921 | 3936 | 6985 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.14 | 0.26 |
| Only index persons | 0.22 | 0.14 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 68.81 | 69.00 | 68.74 |
| Only index persons | 68.09 | 67.78 | 68.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1800 | 537 | 1263 |
| Unadjusted period prevalence (%) | 0.51 | 0.21 | 0.63 |
| Median age at first event (years) | 67.49 | 63.11 | 69.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_OTHANEUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHANEUR | 1.961 [1.71, 2.24] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.329 |
During the follow-up period (1.1.1998 — 31.12.2019), 1280 out of 3386 females with I9_OTHANEUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHANEUR | 2.199 [1.94, 2.49] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2838 out of 6339 males with I9_OTHANEUR died.
Mortality risk
Mortality risk for people of age
years, who have I9_OTHANEUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.435% |
| 5 | 1.375% | 2.475% |
| 10 | 3.182% | 5.979% |
| 15 | 5.664% | 11.079% |
| 20 | 10.035% | 19.115% |
Relationships between endpoints
↥Index endpoint: I9_OTHANEUR – Other aneurysm
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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