No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1069 |
4. Check minimum number of eventsNone |
1069 |
5. Include endpointsNone |
1069 |
6. Filter based on genotype QC (FinnGen only) |
1038 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dissection of aorta
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10468 | 3661 | 6638 |
| Only index persons | 6613 | 2366 | 4247 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.10 | 0.19 |
| Only index persons | 0.14 | 0.09 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 69.07 | 73.63 | 66.56 |
| Only index persons | 68.47 | 73.10 | 65.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1038 | 262 | 776 |
| Unadjusted period prevalence (%) | 0.32 | 0.10 | 0.39 |
| Median age at first event (years) | 66.78 | 67.43 | 66.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_AORTDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTDIS | 2.063 [1.73, 2.46] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.644 |
During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 1366 females with I9_AORTDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTDIS | 1.802 [1.59, 2.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1145 out of 3086 males with I9_AORTDIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_AORTDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.165% | 0.341% |
| 5 | 1.303% | 1.92% |
| 10 | 3.107% | 5.296% |
| 15 | 5.893% | 9.595% |
| 20 | 10.804% | 16.203% |
Relationships between endpoints
↥Index endpoint: I9_AORTDIS – Dissection of aorta
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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