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Hypertension, essential

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSESS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I10
  • Hospital discharge: ICD-9 — 4039A|4019X
  • Hospital discharge: ICD-8 — 401|402|403|404
  • Cause of death: ICD-10 — I10
  • Cause of death: ICD-9 — 4039A|4019X
  • Cause of death: ICD-8 — 401|402|403|404

2 out of 7 registries used, show all original rules.

120723

4. Check minimum number of events

None

120723

5. Include endpoints

None

120723

6. Filter based on genotype QC (FinnGen only)

116714

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I10-I15
Name in latin Hypertensio essentialis (primaria)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1149373 614031 526783
Only index persons 972132 522927 449205
Unadjusted period prevalence (%)
Whole population 16.21 17.59 14.72
Only index persons 18.26 19.22 17.15
Median age at first event (years)
Whole population 67.73 70.23 64.85
Only index persons 67.52 69.91 64.74

-FinnGen-

Key figures

All Female Male
Number of individuals 116714 56748 59966
Unadjusted period prevalence (%) 26.31 22.29 30.12
Median age at first event (years) 64.54 64.25 64.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_HYPTENSESS and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSESS 1.645 [1.52, 1.78] < 0.001
Birth year 0.983 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 141761 out of 443239 females with I9_HYPTENSESS died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSESS 1.776 [1.62, 1.94] < 0.001
Birth year 0.974 [0.97, 0.98] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 115529 out of 379124 males with I9_HYPTENSESS died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSESS.

N-year risk Females Males
1 0.069% 0.15%
5 0.489% 0.901%
10 1.112% 2.26%
15 2.152% 4.316%
20 3.576% 7.412%

Relationships between endpoints

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Index endpoint: I9_HYPTENSESS – Hypertension, essential

GWS hits: 224

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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