hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
142020 |
4. Check minimum number of eventsNone |
142020 |
5. Include endpointsNone |
142020 |
6. Filter based on genotype QC (FinnGen only) |
137312 |
Control definitions (FinnGen only)
Control exclude
I9_HYPERTENSION
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hypertension
based on the number of shared cases.
Similar with more cases:
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1425711 | 748182 | 664286 |
| Only index persons | 1146787 | 608887 | 537900 |
| Unadjusted period prevalence (%) | |||
| Whole population | 20.02 | 21.43 | 18.56 |
| Only index persons | 21.52 | 22.38 | 20.53 |
| Median age at first event (years) | |||
| Whole population | 59.25 | 60.87 | 57.47 |
| Only index persons | 59.13 | 60.74 | 57.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137312 | 65636 | 71676 |
| Unadjusted period prevalence (%) | 31.11 | 25.78 | 36.00 |
| Median age at first event (years) | 57.17 | 57.05 | 57.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENS | 1.252 [1.16, 1.35] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 104587 out of 408173 females with I9_HYPTENS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENS | 1.386 [1.28, 1.5] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 95147 out of 379676 males with I9_HYPTENS died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.072% | 0.219% |
| 5 | 0.486% | 1.216% |
| 10 | 1.196% | 2.963% |
| 15 | 2.292% | 5.774% |
| 20 | 4.09% | 9.463% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENS – Hypertension
GWS hits: 301
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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