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Hypertensive Heart Disease

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSHD

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I11
  • Hospital discharge: ICD-9 — 4029A|4029B
  • Hospital discharge: ICD-8 — 40299
  • Cause of death: ICD-10 — I11
  • Cause of death: ICD-9 — 4029A|4029B
  • Cause of death: ICD-8 — 40299

2 out of 7 registries used, show all original rules.

10721

4. Check minimum number of events

None

10721

5. Include endpoints

None

10721

6. Filter based on genotype QC (FinnGen only)

10283

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I10-I15
Name in latin Morbus hypertensivus cordis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 150300 81772 66217
Only index persons 90945 48409 42536
Unadjusted period prevalence (%)
Whole population 2.13 2.34 1.85
Only index persons 1.71 1.78 1.62
Median age at first event (years)
Whole population 71.15 74.90 66.69
Only index persons 72.84 77.67 67.33

-FinnGen-

Key figures

All Female Male
Number of individuals 10283 4214 6069
Unadjusted period prevalence (%) 2.48 1.66 3.05
Median age at first event (years) 68.83 71.22 67.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_HYPTENSHD and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSHD 1.787 [1.63, 1.96] < 0.001
Birth year 0.995 [0.99, 1.0] 0.195

During the follow-up period (1.1.1998 — 31.12.2019), 16570 out of 32190 females with I9_HYPTENSHD died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSHD 1.941 [1.76, 2.14] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 12513 out of 29835 males with I9_HYPTENSHD died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSHD.

N-year risk Females Males
1 0.196% 0.331%
5 0.983% 1.935%
10 2.615% 4.817%
15 4.846% 9.128%
20 8.294% 14.865%

Relationships between endpoints

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Index endpoint: I9_HYPTENSHD – Hypertensive Heart Disease

GWS hits: 15

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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