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Hypertensive heart and/or renal disease

DOID Endpoint Browser

I9_HYPTENSHR

nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I11, I12, I13
  • Hospital discharge: ICD-9 — 4029A|4029B|4039A|4040A
  • Hospital discharge: ICD-8 — 40299|40399|40499
  • Cause of death: ICD-10 — I11, I12, I13
  • Cause of death: ICD-9 — 4029A|4029B|4039A|4040A
  • Cause of death: ICD-8 — 40299|40399|40499

2 out of 7 registries used, show all original rules.

12152

4. Check minimum number of events

None

12152

5. Include endpoints

12152

6. Filter based on genotype QC (FinnGen only)

11655

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 11655 4659 6996
Unadjusted period prevalence (%) 2.84 1.83 3.51
Median age at first event (years) 68.79 70.91 67.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: I9_HYPTENSHR – Hypertensive heart and/or renal disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).