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Hypertensive heart and/or renal disease


nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

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Endpoint definition

Endpoint definition steps


Phenotype data


1. Apply sex-specific rule



2. Check conditions



3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I11, I12, I13
  • Hospital discharge: ICD-9 4029A|4029B|4039A|4040A
  • Hospital discharge: ICD-8 40299|40399|40499
  • Cause of death: ICD-10 I11, I12, I13
  • Cause of death: ICD-9 4029A|4029B|4039A|4040A
  • Cause of death: ICD-8 40299|40399|40499

2 out of 7 registries used, show all original rules.


4. Check minimum number of events



5. Include endpoints


6. Filter based on genotype QC (FinnGen only)


Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics


This endpoint is excluded from FinRegistry analyses (omitted endpoint).


Key figures

All Female Male
Number of individuals 11655 4659 6996
Unadjusted period prevalence (%) 2.84 1.83 3.51
Median age at first event (years) 68.79 70.91 67.38


Age distribution of first events


Year distribution of first events


Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: I9_HYPTENSHR – Hypertensive heart and/or renal disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).