No definition available.
Heart failure and antihypertensive medication
I9_HEARTFAIL_AND_ANTIHYPERT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
248649 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
32696 |
6. Filter based on genotype QC (FinnGen only) |
31527 |
Control definitions (FinnGen only)
Control conditions
not RX_ANTIHYP
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Heart failure and antihypertensive medication
based on the number of shared cases.
Similar with more cases:
- Heart failure, strict
- Heart failure,strict
- Heart failure, not strict
- Other heart diseases
- Other heart diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 392255 | 208935 | 178711 |
| Only index persons | 291613 | 157423 | 134190 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.52 | 5.98 | 4.99 |
| Only index persons | 5.48 | 5.79 | 5.12 |
| Median age at first event (years) | |||
| Whole population | 74.28 | 76.57 | 71.66 |
| Only index persons | 74.82 | 77.32 | 71.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31527 | 11922 | 19605 |
| Unadjusted period prevalence (%) | 7.89 | 4.68 | 9.85 |
| Median age at first event (years) | 71.10 | 71.66 | 70.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL_AND_ANTIHYPERT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_ANTIHYPERT | 1.736 [1.61, 1.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 86852 out of 140848 females with I9_HEARTFAIL_AND_ANTIHYPERT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_ANTIHYPERT | 2.193 [2.01, 2.39] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 75839 out of 127018 males with I9_HEARTFAIL_AND_ANTIHYPERT died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL_AND_ANTIHYPERT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.118% | 0.378% |
| 5 | 0.829% | 2.13% |
| 10 | 2.101% | 5.094% |
| 15 | 3.707% | 9.263% |
| 20 | 6.318% | 14.907% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL_AND_ANTIHYPERT – Heart failure and antihypertensive medication
GWS hits: 42
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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