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Heart failure, not strict

I9_HEARTFAIL_NS

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I11.0, I13.0, I13.2, I50
  • Hospital discharge: ICD-9 4029B|428
  • Hospital discharge: ICD-8 42700|42710|428|7824
  • Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
  • Cause of death: ICD-9 4029B|428
  • Cause of death: ICD-8 42700|42710|428|7824
  • KELA reimbursements: KELA codes 201
  • Medicine purchases: ATC C03CA01|C03EB01

4 out of 7 registries used, show all original rules.

61166

4. Check minimum number of events

Min. number of events 3
61166

5. Include endpoints

None

61166

6. Filter based on genotype QC (FinnGen only)

58975

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 58975 25678 33297
Unadjusted period prevalence (%) 13.83 10.08 16.72
Median age at first event (years) 69.09 67.88 70.02

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: I9_HEARTFAIL_NS – Heart failure, not strict

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).