systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
34506 |
4. Check minimum number of events
Min. number of events
3, and need other rules
|
34506 |
5. Include endpointsNone |
34506 |
6. Filter based on genotype QC (FinnGen only) |
33250 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Heart failure, strict
based on the number of shared cases.
Similar with more cases:
- Heart failure,strict
- Heart failure, not strict
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 488284 | 258381 | 222422 |
| Only index persons | 306110 | 164935 | 141175 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.87 | 7.40 | 6.21 |
| Only index persons | 5.75 | 6.06 | 5.39 |
| Median age at first event (years) | |||
| Whole population | 73.72 | 75.74 | 71.47 |
| Only index persons | 74.89 | 77.35 | 72.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 33250 | 12476 | 20774 |
| Unadjusted period prevalence (%) | 8.36 | 4.90 | 10.43 |
| Median age at first event (years) | 71.17 | 71.64 | 70.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL | 1.872 [1.73, 2.02] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 93309 out of 148974 females with I9_HEARTFAIL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL | 2.348 [2.15, 2.57] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 81980 out of 134565 males with I9_HEARTFAIL died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.369% |
| 5 | 0.847% | 2.109% |
| 10 | 2.075% | 5.33% |
| 15 | 3.635% | 9.966% |
| 20 | 6.203% | 16.023% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL – Heart failure, strict
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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