No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
52962 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
16183 |
6. Filter based on genotype QC (FinnGen only) |
15579 |
Control definitions (FinnGen only)
Control conditions
not I9_CHD
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Heart failure and coronary heart disease
based on the number of shared cases.
Similar with more cases:
- Heart failure, strict
- Heart failure,strict
- Major coronary heart disease event
- Heart failure, not strict
- Hard cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 230776 | 111300 | 115379 |
| Only index persons | 135233 | 65163 | 70070 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.22 | 3.19 | 3.22 |
| Only index persons | 2.54 | 2.40 | 2.67 |
| Median age at first event (years) | |||
| Whole population | 73.67 | 75.63 | 71.88 |
| Only index persons | 75.15 | 77.47 | 72.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15579 | 4693 | 10886 |
| Unadjusted period prevalence (%) | 4.38 | 1.84 | 5.47 |
| Median age at first event (years) | 71.75 | 72.50 | 71.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL_AND_CHD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_CHD | 1.893 [1.74, 2.06] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 44785 out of 61294 females with I9_HEARTFAIL_AND_CHD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_CHD | 2.141 [1.95, 2.35] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 47710 out of 69657 males with I9_HEARTFAIL_AND_CHD died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL_AND_CHD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.316% |
| 5 | 0.788% | 2.07% |
| 10 | 2.151% | 5.041% |
| 15 | 4.041% | 9.455% |
| 20 | 7.064% | 15.777% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL_AND_CHD – Heart failure and coronary heart disease
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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