cardiovascular disease: A disease involving the cardiovascular system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
75077 |
6. Filter based on genotype QC (FinnGen only) |
72410 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF3
Hard cardiovascular diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1044716 | 434042 | 589344 |
| Only index persons | 588925 | 259263 | 329662 |
| Unadjusted period prevalence (%) | |||
| Whole population | 14.91 | 12.43 | 16.47 |
| Only index persons | 11.24 | 9.53 | 12.58 |
| Median age at first event (years) | |||
| Whole population | 70.01 | 75.13 | 66.33 |
| Only index persons | 69.38 | 74.40 | 65.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 72410 | 24424 | 47986 |
| Unadjusted period prevalence (%) | 19.21 | 9.59 | 24.10 |
| Median age at first event (years) | 66.56 | 68.22 | 65.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CVD_HARD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CVD_HARD | 2.022 [1.87, 2.18] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 103114 out of 212867 females with I9_CVD_HARD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CVD_HARD | 1.77 [1.64, 1.91] | < 0.001 |
| Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 104217 out of 262916 males with I9_CVD_HARD died.
Mortality risk
Mortality risk for people of age
years, who have I9_CVD_HARD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.239% |
| 5 | 0.763% | 1.339% |
| 10 | 1.972% | 3.121% |
| 15 | 3.597% | 5.851% |
| 20 | 6.203% | 9.806% |
Relationships between endpoints
↥Index endpoint: I9_CVD_HARD – Hard cardiovascular diseases
GWS hits: 62
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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