intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersMain diagnosis only: side diagnoses are not checked. Registry filters:
2 out of 7 registries used, show all original rules. |
42100 |
4. Check minimum number of eventsNone |
42100 |
5. Include endpoints |
52962 |
6. Filter based on genotype QC (FinnGen only) |
51098 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Major coronary heart disease event
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 732921 | 276052 | 440492 |
| Only index persons | 390286 | 156444 | 233842 |
| Unadjusted period prevalence (%) | |||
| Whole population | 10.76 | 7.91 | 12.31 |
| Only index persons | 7.65 | 5.75 | 8.93 |
| Median age at first event (years) | |||
| Whole population | 69.86 | 75.87 | 66.19 |
| Only index persons | 69.43 | 75.36 | 65.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 51098 | 15028 | 36070 |
| Unadjusted period prevalence (%) | 14.52 | 5.90 | 18.12 |
| Median age at first event (years) | 66.56 | 69.00 | 65.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CHD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CHD | 1.777 [1.64, 1.92] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 57466 out of 120165 females with I9_CHD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CHD | 1.503 [1.39, 1.63] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 66502 out of 176327 males with I9_CHD died.
Mortality risk
Mortality risk for people of age
years, who have I9_CHD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.183% |
| 5 | 0.94% | 1.407% |
| 10 | 2.199% | 3.379% |
| 15 | 4.095% | 6.386% |
| 20 | 6.943% | 10.695% |
Relationships between endpoints
↥Index endpoint: I9_CHD – Major coronary heart disease event
GWS hits: 90
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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