Coronary Vasospasm: Sudden coronary artery smooth muscle contraction leading to lumen constriction and decreased blood flow.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
17324 |
4. Check minimum number of eventsNone |
17324 |
5. Include endpointsNone |
17324 |
6. Filter based on genotype QC (FinnGen only) |
16749 |
Control definitions (FinnGen only)
Control exclude
I9_ISCHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Coronary angioplasty
based on the number of shared cases.
Similar with more cases:
- Coronary revascularization (ANGIO or CABG)
- Emergency coronary revascularization (for ACS)
- Major coronary heart disease event
- Hard cardiovascular diseases
- Ischemic heart diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 125240 | 40017 | 84719 |
| Only index persons | 116189 | 37179 | 79010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.97 | 1.15 | 2.37 |
| Only index persons | 2.49 | 1.37 | 3.02 |
| Median age at first event (years) | |||
| Whole population | 66.86 | 71.40 | 64.69 |
| Only index persons | 66.69 | 71.31 | 64.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16749 | 4704 | 12045 |
| Unadjusted period prevalence (%) | 4.87 | 1.85 | 6.05 |
| Median age at first event (years) | 65.42 | 67.14 | 64.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_ANGIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ANGIO | 1.207 [1.11, 1.31] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.724 |
During the follow-up period (1.1.1998 — 31.12.2019), 11904 out of 38531 females with I9_ANGIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ANGIO | 1.107 [1.02, 1.2] | 0.017 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 23122 out of 82040 males with I9_ANGIO died.
Mortality risk
Mortality risk for people of age
years, who have I9_ANGIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.246% |
| 5 | 0.922% | 1.364% |
| 10 | 2.022% | 3.659% |
| 15 | 4.101% | 6.657% |
| 20 | 7.43% | 11.136% |
Relationships between endpoints
↥Index endpoint: I9_ANGIO – Coronary angioplasty
GWS hits: 53
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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