No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
27247 |
6. Filter based on genotype QC (FinnGen only) |
26345 |
Control definitions (FinnGen only)
Control exclude
I9_ISCHHEART
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Coronary revascularization (ANGIO or CABG)
based on the number of shared cases.
Similar with more cases:
- Emergency coronary revascularization (for ACS)
- Major coronary heart disease event
- Hard cardiovascular diseases
- Ischemic heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 199943 | 57410 | 141061 |
| Only index persons | 174766 | 50931 | 123835 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.26 | 1.64 | 3.94 |
| Only index persons | 3.90 | 1.87 | 4.73 |
| Median age at first event (years) | |||
| Whole population | 66.55 | 70.90 | 64.75 |
| Only index persons | 66.29 | 70.76 | 64.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26345 | 6303 | 20042 |
| Unadjusted period prevalence (%) | 8.25 | 2.48 | 10.07 |
| Median age at first event (years) | 64.89 | 67.08 | 64.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_REVASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_REVASC | 1.308 [1.21, 1.41] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 17831 out of 50368 females with I9_REVASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_REVASC | 1.153 [1.07, 1.24] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 38902 out of 119548 males with I9_REVASC died.
Mortality risk
Mortality risk for people of age
years, who have I9_REVASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.193% |
| 5 | 0.621% | 1.153% |
| 10 | 1.487% | 2.98% |
| 15 | 2.866% | 5.849% |
| 20 | 4.893% | 9.683% |
Relationships between endpoints
↥Index endpoint: I9_REVASC – Coronary revascularization (ANGIO or CABG)
GWS hits: 111
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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