Coronary Vasospasm: Sudden coronary artery smooth muscle contraction leading to lumen constriction and decreased blood flow.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
12893 |
4. Check minimum number of eventsNone |
12893 |
5. Include endpointsNone |
12893 |
6. Filter based on genotype QC (FinnGen only) |
12461 |
Control definitions (FinnGen only)
Control exclude
I9_ISCHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF10
Similar endpoints
↥List of similar endpoints to
Coronary artery bypass grafting
based on the number of shared cases.
Similar with more cases:
- Coronary revascularization (ANGIO or CABG)
- Emergency coronary revascularization (for ACS)
- Major coronary heart disease event
- Hard cardiovascular diseases
- Ischemic heart diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 89489 | 20741 | 67703 |
| Only index persons | 72151 | 16822 | 55329 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.58 | 0.59 | 1.89 |
| Only index persons | 1.76 | 0.62 | 2.11 |
| Median age at first event (years) | |||
| Whole population | 66.57 | 70.38 | 65.38 |
| Only index persons | 66.26 | 70.10 | 65.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12461 | 2102 | 10359 |
| Unadjusted period prevalence (%) | 4.46 | 0.83 | 5.20 |
| Median age at first event (years) | 65.03 | 67.55 | 64.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CABG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CABG | 1.436 [1.35, 1.53] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 7261 out of 14959 females with I9_CABG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CABG | 1.155 [1.08, 1.23] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 19729 out of 48129 males with I9_CABG died.
Mortality risk
Mortality risk for people of age
years, who have I9_CABG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.157% | 0.189% |
| 5 | 0.794% | 1.15% |
| 10 | 1.949% | 2.817% |
| 15 | 3.828% | 5.685% |
| 20 | 6.729% | 9.521% |
Relationships between endpoints
↥Index endpoint: I9_CABG – Coronary artery bypass grafting
GWS hits: 74
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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