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Myocardial infarction, strict

DOID EFO Endpoint Browser PheWeb

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Main diagnosis only: side diagnoses are not checked.

Registry filters:

  • Hospital discharge: ICD-10 — I21, I22
  • Hospital discharge: ICD-9 — 410
  • Hospital discharge: ICD-8 — 410
  • Hospital discharge: excluded ICD-10 — I21.90, I21.97, I22.90, I22.97
  • Cause of death: ICD-10 — I21, I22
  • Cause of death: ICD-9 — 410
  • Cause of death: ICD-8 — 410
  • Cause of death: excluded ICD-10 — I21.90, I21.97, I22.90, I22.97

2 out of 7 registries used, show all original rules.

29672

4. Check minimum number of events

None

29672

5. Include endpoints

None

29672

6. Filter based on genotype QC (FinnGen only)

28546

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 463154 166806 284587
Only index persons 216802 83212 133590
Unadjusted period prevalence (%)
Whole population 6.92 4.78 7.95
Only index persons 4.32 3.06 5.10
Median age at first event (years)
Whole population 69.65 75.90 66.10
Only index persons 69.63 76.53 65.34

-FinnGen-

Key figures

All Female Male
Number of individuals 28546 7645 20901
Unadjusted period prevalence (%) 8.49 3.00 10.50
Median age at first event (years) 67.11 70.67 65.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_MI_STRICT and mortality.

Females

Parameter HR [95% CI] p-value
I9_MI_STRICT 1.911 [1.75, 2.08] < 0.001
Birth year 0.993 [0.98, 1.0] 0.059

During the follow-up period (1.1.1998 — 31.12.2019), 36413 out of 66544 females with I9_MI_STRICT died.

Males

Parameter HR [95% CI] p-value
I9_MI_STRICT 1.74 [1.59, 1.9] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 40448 out of 99273 males with I9_MI_STRICT died.

Mortality risk

Mortality risk for people of age

years, who have I9_MI_STRICT.

N-year risk Females Males
1 0.154% 0.204%
5 0.961% 1.551%
10 2.548% 3.994%
15 4.673% 7.468%
20 7.911% 12.775%

Relationships between endpoints

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Index endpoint: I9_MI_STRICT – Myocardial infarction, strict

GWS hits: 55

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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