≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Ischaemic heart disease, wide definition

DOID EFO Endpoint Browser PheWeb

I9_IHD

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I20-I25
  • Hospital discharge: ICD-9 — 41[0-4]
  • Hospital discharge: ICD-8 — 41[0-4]
  • Cause of death: ICD-10 — I21, I22, I23, I24, I25, I46, R96, R98
  • Cause of death: ICD-9 — 41[0-4]|798
  • Cause of death: ICD-8 — 41[0-4]|798
  • Cause of death: excluded ICD-9 — 7980A
  • KELA reimbursements: KELA codes — 206

3 out of 7 registries used, show all original rules.

78346

4. Check minimum number of events

None

78346

5. Include endpoints

None

78346

6. Filter based on genotype QC (FinnGen only)

75592

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1023060 426636 575441
Only index persons 579760 259579 320181
Unadjusted period prevalence (%)
Whole population 14.59 12.22 16.08
Only index persons 11.02 9.54 12.22
Median age at first event (years)
Whole population 67.45 71.65 64.39
Only index persons 66.40 70.13 63.38

-FinnGen-

Key figures

All Female Male
Number of individuals 75592 25890 49702
Unadjusted period prevalence (%) 19.89 10.17 24.96
Median age at first event (years) 64.29 65.19 63.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_IHD and mortality.

Females

Parameter HR [95% CI] p-value
I9_IHD 1.542 [1.44, 1.65] < 0.001
Birth year 0.993 [0.99, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 86775 out of 192815 females with I9_IHD died.

Males

Parameter HR [95% CI] p-value
I9_IHD 1.486 [1.38, 1.61] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 84922 out of 231019 males with I9_IHD died.

Mortality risk

Mortality risk for people of age

years, who have I9_IHD.

N-year risk Females Males
1 0.087% 0.201%
5 0.676% 1.301%
10 1.76% 3.126%
15 3.403% 6.022%
20 5.892% 10.138%

Relationships between endpoints

↥

Index endpoint: I9_IHD – Ischaemic heart disease, wide definition

GWS hits: 86

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data