intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
16326 |
4. Check minimum number of eventsNone |
16326 |
5. Include endpointsNone |
16326 |
6. Filter based on genotype QC (FinnGen only) |
15717 |
Control definitions (FinnGen only)
Control exclude
I9_CHD
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I20
Name in latin
Angina pectoris instabilis
Similar endpoints
↥List of similar endpoints to
Unstable angina pectoris
based on the number of shared cases.
Similar with more cases:
- Angina pectoris
- Ischaemic heart disease, wide definition
- Ischemic heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 142717 | 57674 | 83464 |
| Only index persons | 111648 | 45301 | 66347 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.05 | 1.65 | 2.33 |
| Only index persons | 2.18 | 1.67 | 2.53 |
| Median age at first event (years) | |||
| Whole population | 69.69 | 73.48 | 67.03 |
| Only index persons | 68.23 | 72.05 | 65.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15717 | 5300 | 10417 |
| Unadjusted period prevalence (%) | 4.17 | 2.08 | 5.23 |
| Median age at first event (years) | 66.58 | 67.82 | 65.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_UAP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_UAP | 1.496 [1.39, 1.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.16 |
During the follow-up period (1.1.1998 — 31.12.2019), 21744 out of 45173 females with I9_UAP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_UAP | 1.497 [1.38, 1.62] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 27870 out of 64905 males with I9_UAP died.
Mortality risk
Mortality risk for people of age
years, who have I9_UAP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.207% |
| 5 | 0.824% | 1.423% |
| 10 | 2.124% | 3.601% |
| 15 | 4.008% | 6.524% |
| 20 | 7.33% | 10.843% |
Relationships between endpoints
↥Index endpoint: I9_UAP – Unstable angina pectoris
GWS hits: 26
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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