Unstable angina pectoris

I9_UAP

intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I20.0
  • Hospital discharge: ICD-9 4110
  • Cause of death: ICD-10 I20.0
  • Cause of death: ICD-9 4110

2 out of 7 registries used, show all original rules.

16326

4. Check minimum number of events

None

16326

5. Include endpoints

None

16326

6. Filter based on genotype QC (FinnGen only)

15717

Control definitions (FinnGen only)

Control exclude I9_CHD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I20
Name in latin Angina pectoris instabilis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 142717 57674 83464
Only index persons 111648 45301 66347
Unadjusted period prevalence (%)
Whole population 2.05 1.65 2.33
Only index persons 2.18 1.67 2.53
Median age at first event (years)
Whole population 69.69 73.48 67.03
Only index persons 68.23 72.05 65.61

-FinnGen-

Key figures

All Female Male
Number of individuals 15717 5300 10417
Unadjusted period prevalence (%) 4.17 2.08 5.23
Median age at first event (years) 66.58 67.82 65.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint I9_UAP and mortality.

Females

Parameter HR [95% CI] p-value
I9_UAP 1.496 [1.39, 1.61] < 0.001
Birth year 0.994 [0.99, 1.0] 0.16

During the follow-up period (1.1.1998 — 31.12.2019), 21744 out of 45173 females with I9_UAP died.

Males

Parameter HR [95% CI] p-value
I9_UAP 1.497 [1.38, 1.62] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 27870 out of 64905 males with I9_UAP died.

Mortality risk

Mortality risk for people of age

years, who have I9_UAP.

N-year risk Females Males
1 0.135% 0.207%
5 0.824% 1.423%
10 2.124% 3.601%
15 4.008% 6.524%
20 7.33% 10.843%

Relationships between endpoints

Index endpoint: I9_UAP – Unstable angina pectoris

GWS hits: 26

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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