≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Angina pectoris

DOID EFO Endpoint Browser PheWeb

I9_ANGINA

Prinzmetal's angina: a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I20
  • Hospital discharge: ICD-9 — 413|411[0-1]
  • Hospital discharge: ICD-8 — 413
  • Cause of death: ICD-10 — I20
  • Cause of death: ICD-9 — 413|411[0-1]
  • Cause of death: ICD-8 — 413

2 out of 7 registries used, show all original rules.

41891

4. Check minimum number of events

None

41891

5. Include endpoints

None

41891

6. Filter based on genotype QC (FinnGen only)

40366

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I20-I25
Name in latin Angina pectoris

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 430780 181814 242255
Only index persons 286312 121758 164554
Unadjusted period prevalence (%)
Whole population 6.11 5.21 6.77
Only index persons 5.51 4.48 6.28
Median age at first event (years)
Whole population 66.20 69.67 63.56
Only index persons 64.60 67.84 62.21

-FinnGen-

Key figures

All Female Male
Number of individuals 40366 13714 26652
Unadjusted period prevalence (%) 10.67 5.39 13.39
Median age at first event (years) 63.41 64.44 62.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_ANGINA and mortality.

Females

Parameter HR [95% CI] p-value
I9_ANGINA 1.409 [1.32, 1.51] < 0.001
Birth year 0.998 [0.99, 1.01] 0.561

During the follow-up period (1.1.1998 — 31.12.2019), 46177 out of 103906 females with I9_ANGINA died.

Males

Parameter HR [95% CI] p-value
I9_ANGINA 1.325 [1.23, 1.42] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 55698 out of 140207 males with I9_ANGINA died.

Mortality risk

Mortality risk for people of age

years, who have I9_ANGINA.

N-year risk Females Males
1 0.139% 0.209%
5 0.763% 1.173%
10 1.937% 2.973%
15 3.712% 5.579%
20 6.711% 9.479%

Relationships between endpoints

↥

Index endpoint: I9_ANGINA – Angina pectoris

GWS hits: 76

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data