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Stroke, excluding SAH

DOID EFO Endpoint Browser PheWeb

I9_STR

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I61, I63, I64
  • Hospital discharge: ICD-9 — 431|4330A|4331A|4339A|4340A|4341A|4349A|436
  • Hospital discharge: ICD-8 — 431|433|434|436
  • Hospital discharge: excluded ICD-10 — I63.6
  • Hospital discharge: excluded ICD-8 — 43101|43191
  • Cause of death: ICD-10 — I61, I63, I64
  • Cause of death: ICD-9 — 431|4330A|4331A|4339A|4340A|4341A|4349A|436
  • Cause of death: ICD-8 — 431|433|434|436
  • Cause of death: excluded ICD-10 — I63.6
  • Cause of death: excluded ICD-8 — 43101|43191

2 out of 7 registries used, show all original rules.

31674

4. Check minimum number of events

None

31674

5. Include endpoints

None

31674

6. Filter based on genotype QC (FinnGen only)

30521

Control definitions (FinnGen only)

Control exclude I9_STR_EXH, I9_TIA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 442894 213432 221786
Only index persons 272780 134306 138474
Unadjusted period prevalence (%)
Whole population 6.19 6.11 6.20
Only index persons 5.11 4.94 5.29
Median age at first event (years)
Whole population 72.64 76.00 69.48
Only index persons 71.92 75.42 68.53

-FinnGen-

Key figures

All Female Male
Number of individuals 30521 11923 18598
Unadjusted period prevalence (%) 7.52 4.68 9.34
Median age at first event (years) 69.22 69.25 69.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_STR and mortality.

Females

Parameter HR [95% CI] p-value
I9_STR 2.239 [2.06, 2.44] < 0.001
Birth year 0.991 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 63261 out of 118634 females with I9_STR died.

Males

Parameter HR [95% CI] p-value
I9_STR 2.122 [1.94, 2.32] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 60806 out of 123865 males with I9_STR died.

Mortality risk

Mortality risk for people of age

years, who have I9_STR.

N-year risk Females Males
1 0.195% 0.395%
5 1.036% 2.072%
10 2.433% 4.852%
15 4.801% 8.961%
20 7.966% 15.165%

Relationships between endpoints

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Index endpoint: I9_STR – Stroke, excluding SAH

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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