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Transient ischemic attack

DOID EFO Endpoint Browser PheWeb

I9_TIA

transient ischemic attack: A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G45
  • Hospital discharge: ICD-9 — 435
  • Hospital discharge: ICD-8 — 435
  • Hospital discharge: excluded ICD-10 — G45.4
  • Cause of death: ICD-10 — G45
  • Cause of death: ICD-9 — 435
  • Cause of death: ICD-8 — 435
  • Cause of death: excluded ICD-10 — G45.4

2 out of 7 registries used, show all original rules.

22935

4. Check minimum number of events

None

22935

5. Include endpoints

None

22935

6. Filter based on genotype QC (FinnGen only)

22199

Control definitions (FinnGen only)

Control exclude I9_STR_EXH

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Ischaemia cerebri transitoria et syndomata cognata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 232804 121486 109011
Only index persons 178956 95529 83427
Unadjusted period prevalence (%)
Whole population 3.27 3.48 3.05
Only index persons 3.36 3.51 3.18
Median age at first event (years)
Whole population 70.63 72.65 68.39
Only index persons 69.40 71.31 67.21

-FinnGen-

Key figures

All Female Male
Number of individuals 22199 10523 11676
Unadjusted period prevalence (%) 5.04 4.13 5.86
Median age at first event (years) 66.91 66.24 67.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_TIA and mortality.

Females

Parameter HR [95% CI] p-value
I9_TIA 1.356 [1.25, 1.47] < 0.001
Birth year 0.992 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 33767 out of 88686 females with I9_TIA died.

Males

Parameter HR [95% CI] p-value
I9_TIA 1.432 [1.31, 1.57] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 30287 out of 78551 males with I9_TIA died.

Mortality risk

Mortality risk for people of age

years, who have I9_TIA.

N-year risk Females Males
1 0.113% 0.23%
5 0.64% 1.503%
10 1.835% 3.431%
15 3.448% 6.296%
20 5.997% 10.716%

Relationships between endpoints

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Index endpoint: I9_TIA – Transient ischemic attack

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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