nervous system disease: A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10749 |
4. Check minimum number of eventsNone |
10749 |
5. Include endpoints |
34487 |
6. Filter based on genotype QC (FinnGen only) |
33364 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other neurological diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 330757 | 170452 | 157069 |
| Only index persons | 258723 | 137531 | 121192 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.63 | 4.88 | 4.39 |
| Only index persons | 4.85 | 5.06 | 4.63 |
| Median age at first event (years) | |||
| Whole population | 67.23 | 68.92 | 65.36 |
| Only index persons | 65.53 | 66.91 | 63.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 33364 | 16780 | 16584 |
| Unadjusted period prevalence (%) | 7.45 | 6.59 | 8.33 |
| Median age at first event (years) | 63.40 | 61.07 | 65.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_OTHNEU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHNEU | 1.468 [1.36, 1.59] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 41418 out of 123754 females with G6_OTHNEU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHNEU | 1.617 [1.48, 1.76] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 39902 out of 110413 males with G6_OTHNEU died.
Mortality risk
Mortality risk for people of age
years, who have G6_OTHNEU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.258% |
| 5 | 0.642% | 1.506% |
| 10 | 1.718% | 3.829% |
| 15 | 3.126% | 7.145% |
| 20 | 5.684% | 11.743% |
Relationships between endpoints
↥Index endpoint: G6_OTHNEU – Other neurological diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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