nervous system disease: A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2803 |
4. Check minimum number of eventsNone |
2803 |
5. Include endpointsNone |
2803 |
6. Filter based on genotype QC (FinnGen only) |
2709 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Morbositates systematis nervosi post interventiones non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Postprocedural disorders of nervous system
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17984 | 12561 | 5331 |
| Only index persons | 17409 | 12324 | 5085 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.30 | 0.36 | 0.15 |
| Only index persons | 0.38 | 0.45 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 34.51 | 34.74 | 33.96 |
| Only index persons | 34.38 | 34.68 | 33.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2709 | 2095 | 614 |
| Unadjusted period prevalence (%) | 0.71 | 0.82 | 0.31 |
| Median age at first event (years) | 37.03 | 36.20 | 39.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_POSTOPNEURO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_POSTOPNEURO | 1.074 [0.92, 1.25] | 0.355 |
| Birth year | 0.993 [0.98, 1.0] | 0.098 |
During the follow-up period (1.1.1998 — 31.12.2019), 273 out of 10559 females with G6_POSTOPNEURO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_POSTOPNEURO | 1.037 [0.9, 1.2] | 0.615 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 4412 males with G6_POSTOPNEURO died.
Mortality risk
Mortality risk for people of age
years, who have G6_POSTOPNEURO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.219% |
| 5 | 0.627% | 1.243% |
| 10 | 1.585% | 3.256% |
| 15 | 2.824% | 6.215% |
| 20 | 4.87% | 10.678% |
Relationships between endpoints
↥Index endpoint: G6_POSTOPNEURO – Postprocedural disorders of nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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