central nervous system disease: A disease involving the central nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
381 |
4. Check minimum number of eventsNone |
381 |
5. Include endpointsNone |
381 |
6. Filter based on genotype QC (FinnGen only) |
368 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Aliae morbositates systematis nervosi centralis
Similar endpoints
↥List of similar endpoints to
Other disorders of central nervous system
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3599 | 1799 | 1755 |
| Only index persons | 2683 | 1459 | 1224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 51.05 | 50.08 | 51.69 |
| Only index persons | 46.73 | 46.94 | 46.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 368 | 223 | 145 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | 48.52 | 44.86 | 54.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_CNSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSOTH | 2.546 [1.94, 3.33] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.811 |
During the follow-up period (1.1.1998 — 31.12.2019), 160 out of 1017 females with G6_CNSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSOTH | 2.416 [1.86, 3.13] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 815 males with G6_CNSOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_CNSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.256% | 0.513% |
| 5 | 1.547% | 2.716% |
| 10 | 3.976% | 7.605% |
| 15 | 7.418% | 14.388% |
| 20 | 12.607% | 23.066% |
Relationships between endpoints
↥Index endpoint: G6_CNSOTH – Other disorders of central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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