Other disorders of nervous system

G6_NEUROOTH

nervous system disease: A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G98, G99*
  • Cause of death: ICD-10 G98, G99*

2 out of 7 registries used, show all original rules.

2257

4. Check minimum number of events

None

2257

5. Include endpoints

None

2257

6. Filter based on genotype QC (FinnGen only)

2166

Control definitions (FinnGen only)

Control exclude G6_OTHNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13637 6281 7307
Only index persons 12774 5937 6837
Unadjusted period prevalence (%)
Whole population 0.19 0.18 0.20
Only index persons 0.24 0.22 0.26
Median age at first event (years)
Whole population 58.90 59.38 58.44
Only index persons 58.38 58.76 58.05

-FinnGen-

Key figures

All Female Male
Number of individuals 2166 1079 1087
Unadjusted period prevalence (%) 0.49 0.42 0.55
Median age at first event (years) 58.94 57.20 60.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint G6_NEUROOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_NEUROOTH 1.537 [1.37, 1.72] < 0.001
Birth year 0.994 [0.98, 1.0] 0.136

During the follow-up period (1.1.1998 — 31.12.2019), 1028 out of 5356 females with G6_NEUROOTH died.

Males

Parameter HR [95% CI] p-value
G6_NEUROOTH 1.566 [1.4, 1.75] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1427 out of 6181 males with G6_NEUROOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_NEUROOTH.

N-year risk Females Males
1 0.143% 0.305%
5 0.884% 1.664%
10 2.071% 4.471%
15 4.006% 8.346%
20 6.955% 13.924%

Relationships between endpoints

Index endpoint: G6_NEUROOTH – Other disorders of nervous system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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