brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
308 |
4. Check minimum number of eventsNone |
308 |
5. Include endpointsNone |
308 |
6. Filter based on genotype QC (FinnGen only) |
295 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G93
Name in latin
Encephalopathia non specificata
Similar endpoints
↥List of similar endpoints to
Encephalopathy
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4284 | 1649 | 2575 |
| Only index persons | 2826 | 1169 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 60.73 | 60.46 | 60.73 |
| Only index persons | 58.69 | 58.57 | 58.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 295 | 108 | 187 |
| Unadjusted period prevalence (%) | 0.08 | 0.04 | 0.09 |
| Median age at first event (years) | 60.13 | 57.34 | 61.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPATH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 5.197 [4.2, 6.43] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.725 |
During the follow-up period (1.1.1998 — 31.12.2019), 510 out of 1064 females with G6_ENCEPATH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 4.951 [4.13, 5.93] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 805 out of 1493 males with G6_ENCEPATH died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPATH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.72% |
| 5 | 3.665% | 5.005% |
| 10 | 8.454% | 11.984% |
| 15 | 15.556% | 22.374% |
| 20 | 26.651% | 35.56% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPATH – Encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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