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Disorders of brain, other and unspecified

DOID EFO Endpoint Browser PheWeb

G6_DISBROTHUNS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G93.8, G93.90, G93.99, G94.8*
  • Hospital discharge: ICD-9 — 348[8-9]
  • Hospital discharge: ICD-8 — 3479[8-9]
  • Cause of death: ICD-10 — G93.8, G93.90, G93.99, G94.8*
  • Cause of death: ICD-9 — 348[8-9]
  • Cause of death: ICD-8 — 3479[8-9]

2 out of 7 registries used, show all original rules.

323

4. Check minimum number of events

None

323

5. Include endpoints

None

323

6. Filter based on genotype QC (FinnGen only)

312

Control definitions (FinnGen only)

Control exclude G6_OTHNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4808 2024 2697
Only index persons 2930 1376 1554
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 48.81 47.92 49.20
Only index persons 41.61 43.17 40.23

-FinnGen-

Key figures

All Female Male
Number of individuals 312 131 181
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 47.53 42.25 51.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_DISBROTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_DISBROTHUNS 3.99 [2.68, 5.94] < 0.001
Birth year 0.998 [0.99, 1.01] 0.697

During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 487 females with G6_DISBROTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_DISBROTHUNS 4.946 [3.66, 6.68] < 0.001
Birth year 0.99 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 545 males with G6_DISBROTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_DISBROTHUNS.

N-year risk Females Males
1 0.44% 0.838%
5 2.171% 5.642%
10 6.164% 14.249%
15 11.626% 26.237%
20 20.3% 41.219%

Relationships between endpoints

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Index endpoint: G6_DISBROTHUNS – Disorders of brain, other and unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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