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Other diseases of spinal cord

DOID EFO Endpoint Browser PheWeb

G6_SPINOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G95
  • Hospital discharge: ICD-9 — 336
  • Hospital discharge: ICD-8 — 349
  • Cause of death: ICD-10 — G95
  • Cause of death: ICD-9 — 336
  • Cause of death: ICD-8 — 349

2 out of 7 registries used, show all original rules.

1009

4. Check minimum number of events

None

1009

5. Include endpoints

None

1009

6. Filter based on genotype QC (FinnGen only)

975

Control definitions (FinnGen only)

Control exclude G6_OTHNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G90-G99

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9073 4166 4815
Only index persons 7450 3565 3885
Unadjusted period prevalence (%)
Whole population 0.13 0.12 0.13
Only index persons 0.14 0.13 0.15
Median age at first event (years)
Whole population 53.28 52.68 53.64
Only index persons 51.72 51.16 52.23

-FinnGen-

Key figures

All Female Male
Number of individuals 975 495 480
Unadjusted period prevalence (%) 0.22 0.19 0.24
Median age at first event (years) 52.18 48.89 55.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_SPINOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_SPINOTH 2.357 [2.03, 2.73] < 0.001
Birth year 0.994 [0.99, 1.0] 0.146

During the follow-up period (1.1.1998 — 31.12.2019), 600 out of 2883 females with G6_SPINOTH died.

Males

Parameter HR [95% CI] p-value
G6_SPINOTH 2.303 [2.02, 2.62] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 902 out of 3328 males with G6_SPINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_SPINOTH.

N-year risk Females Males
1 0.185% 0.515%
5 1.342% 2.816%
10 3.579% 7.176%
15 6.771% 13.09%
20 11.097% 21.615%

Relationships between endpoints

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Index endpoint: G6_SPINOTH – Other diseases of spinal cord

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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