No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
49529 |
6. Filter based on genotype QC (FinnGen only) |
47841 |
Control definitions (FinnGen only)
Control exclude
DM_COMORB
Extra metadata
First used in FinnGen datafreeze
DF2
STROKE
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 620742 | 307731 | 303451 |
| Only index persons | 405606 | 206981 | 198625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.67 | 8.81 | 8.48 |
| Only index persons | 7.60 | 7.61 | 7.58 |
| Median age at first event (years) | |||
| Whole population | 70.72 | 73.55 | 67.90 |
| Only index persons | 69.63 | 72.31 | 66.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 47841 | 20676 | 27165 |
| Unadjusted period prevalence (%) | 11.26 | 8.12 | 13.64 |
| Median age at first event (years) | 66.97 | 66.11 | 67.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C_STROKE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C_STROKE | 1.9 [1.76, 2.05] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 81235 out of 180487 females with C_STROKE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C_STROKE | 1.911 [1.76, 2.08] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 76329 out of 175460 males with C_STROKE died.
Mortality risk
Mortality risk for people of age
years, who have C_STROKE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.285% |
| 5 | 0.926% | 1.761% |
| 10 | 2.16% | 4.11% |
| 15 | 4.09% | 7.596% |
| 20 | 7.177% | 12.453% |
Relationships between endpoints
↥Index endpoint: C_STROKE – STROKE
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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