cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3931 |
4. Check minimum number of eventsNone |
3931 |
5. Include endpointsNone |
3931 |
6. Filter based on genotype QC (FinnGen only) |
3814 |
Control definitions (FinnGen only)
Control exclude
I9_STR_EXH, I9_TIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I60-I69
Name in latin
Haemorrhagia subarachnoidalis
Similar endpoints
↥List of similar endpoints to
Subarachnoid haemorrhage
based on the number of shared cases.
Similar with more cases:
- Aneurysms, operations, SAH
- Nontraumatic intracranial haemmorrhage
- Stroke, including SAH
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 48665 | 24683 | 23067 |
| Only index persons | 28228 | 14996 | 13232 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.68 | 0.71 | 0.64 |
| Only index persons | 0.53 | 0.55 | 0.51 |
| Median age at first event (years) | |||
| Whole population | 56.90 | 58.99 | 54.65 |
| Only index persons | 56.20 | 57.69 | 54.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3814 | 1967 | 1847 |
| Unadjusted period prevalence (%) | 0.85 | 0.77 | 0.93 |
| Median age at first event (years) | 54.93 | 54.12 | 55.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_SAH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SAH | 2.296 [2.07, 2.55] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.376 |
During the follow-up period (1.1.1998 — 31.12.2019), 2845 out of 9406 females with I9_SAH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SAH | 2.236 [2.01, 2.49] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 2937 out of 8674 males with I9_SAH died.
Mortality risk
Mortality risk for people of age
years, who have I9_SAH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.502% |
| 5 | 1.169% | 2.812% |
| 10 | 3.511% | 6.629% |
| 15 | 6.527% | 12.855% |
| 20 | 11.833% | 21.177% |
Relationships between endpoints
↥Index endpoint: I9_SAH – Subarachnoid haemorrhage
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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