No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
8034 |
6. Filter based on genotype QC (FinnGen only) |
7763 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Nontraumatic intracranial haemmorrhage
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 120107 | 57004 | 60805 |
| Only index persons | 69638 | 34146 | 35492 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.68 | 1.63 | 1.70 |
| Only index persons | 1.31 | 1.26 | 1.35 |
| Median age at first event (years) | |||
| Whole population | 66.34 | 69.20 | 63.72 |
| Only index persons | 66.62 | 69.27 | 64.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7763 | 3425 | 4338 |
| Unadjusted period prevalence (%) | 1.81 | 1.35 | 2.18 |
| Median age at first event (years) | 63.40 | 60.60 | 65.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_INTRACRA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_INTRACRA | 2.591 [2.34, 2.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 10433 out of 23218 females with I9_INTRACRA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_INTRACRA | 2.552 [2.3, 2.83] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 11486 out of 25311 males with I9_INTRACRA died.
Mortality risk
Mortality risk for people of age
years, who have I9_INTRACRA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | 0.367% |
| 5 | 1.26% | 2.51% |
| 10 | 3.11% | 7.178% |
| 15 | 6.083% | 12.82% |
| 20 | 10.536% | 20.875% |
Relationships between endpoints
↥Index endpoint: I9_INTRACRA – Nontraumatic intracranial haemmorrhage
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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