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Intracerebral haemorrhage

DOID EFO Endpoint Browser PheWeb

I9_ICH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I61
  • Hospital discharge: ICD-9 — 431
  • Hospital discharge: ICD-8 — 431
  • Cause of death: ICD-10 — I61
  • Cause of death: ICD-9 — 431
  • Cause of death: ICD-8 — 431

2 out of 7 registries used, show all original rules.

4723

4. Check minimum number of events

None

4723

5. Include endpoints

None

4723

6. Filter based on genotype QC (FinnGen only)

4542

Control definitions (FinnGen only)

Control exclude I9_STR_EXH, I9_TIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I60-I69
Name in latin Haemorrhagia intracerebralis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 79457 36219 41747
Only index persons 46894 21914 24980
Unadjusted period prevalence (%)
Whole population 1.11 1.04 1.17
Only index persons 0.88 0.81 0.95
Median age at first event (years)
Whole population 70.68 74.26 67.66
Only index persons 71.33 75.26 67.88

-FinnGen-

Key figures

All Female Male
Number of individuals 4542 1759 2783
Unadjusted period prevalence (%) 1.12 0.69 1.40
Median age at first event (years) 70.38 70.18 70.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_ICH and mortality.

Females

Parameter HR [95% CI] p-value
I9_ICH 2.719 [2.45, 3.02] < 0.001
Birth year 0.991 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 8418 out of 15911 females with I9_ICH died.

Males

Parameter HR [95% CI] p-value
I9_ICH 2.682 [2.41, 2.99] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 9468 out of 18816 males with I9_ICH died.

Mortality risk

Mortality risk for people of age

years, who have I9_ICH.

N-year risk Females Males
1 0.171% 0.377%
5 1.531% 2.647%
10 3.57% 6.822%
15 6.276% 12.305%
20 11.045% 20.278%

Relationships between endpoints

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Index endpoint: I9_ICH – Intracerebral haemorrhage

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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