No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
6415 |
6. Filter based on genotype QC (FinnGen only) |
6236 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Aneurysms, operations, SAH
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 62174 | 32691 | 28490 |
| Only index persons | 40631 | 22510 | 18121 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.87 | 0.94 | 0.80 |
| Only index persons | 0.77 | 0.83 | 0.69 |
| Median age at first event (years) | |||
| Whole population | 57.71 | 59.42 | 55.75 |
| Only index persons | 57.42 | 58.55 | 56.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6236 | 3525 | 2711 |
| Unadjusted period prevalence (%) | 1.37 | 1.38 | 1.36 |
| Median age at first event (years) | 56.62 | 55.97 | 57.46 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_SAHANEUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SAHANEUR | 2.173 [1.97, 2.4] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 3919 out of 15897 females with I9_SAHANEUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SAHANEUR | 2.285 [2.06, 2.53] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3963 out of 13030 males with I9_SAHANEUR died.
Mortality risk
Mortality risk for people of age
years, who have I9_SAHANEUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.19% | 0.36% |
| 5 | 1.138% | 2.232% |
| 10 | 2.866% | 5.538% |
| 15 | 5.712% | 10.532% |
| 20 | 9.658% | 17.186% |
Relationships between endpoints
↥Index endpoint: I9_SAHANEUR – Aneurysms, operations, SAH
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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