brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3084 |
4. Check minimum number of eventsNone |
3084 |
5. Include endpointsNone |
3084 |
6. Filter based on genotype QC (FinnGen only) |
3014 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Aneurysma encephali non ruptum
Similar endpoints
↥List of similar endpoints to
Cerebral aneurysm, nonruptured
based on the number of shared cases.
Similar with more cases:
- Aneurysms, operations, SAH
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17142 | 10253 | 6792 |
| Only index persons | 15532 | 9499 | 6033 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.29 | 0.19 |
| Only index persons | 0.30 | 0.35 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 59.51 | 60.10 | 58.55 |
| Only index persons | 58.88 | 59.32 | 58.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3014 | 1938 | 1076 |
| Unadjusted period prevalence (%) | 0.68 | 0.76 | 0.54 |
| Median age at first event (years) | 58.02 | 57.48 | 59.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_ANEURYSM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ANEURYSM | 2.021 [1.8, 2.27] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.366 |
During the follow-up period (1.1.1998 — 31.12.2019), 1412 out of 8126 females with I9_ANEURYSM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ANEURYSM | 1.977 [1.76, 2.22] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 1268 out of 5324 males with I9_ANEURYSM died.
Mortality risk
Mortality risk for people of age
years, who have I9_ANEURYSM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.174% | 0.347% |
| 5 | 1.132% | 2.357% |
| 10 | 3.003% | 6.196% |
| 15 | 5.76% | 11.634% |
| 20 | 9.92% | 19.211% |
Relationships between endpoints
↥Index endpoint: I9_ANEURYSM – Cerebral aneurysm, nonruptured
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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