No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1013 |
4. Check minimum number of eventsNone |
1013 |
5. Include endpointsNone |
1013 |
6. Filter based on genotype QC (FinnGen only) |
981 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I60-I69
Name in latin
Alia haemorrhagia intracranialis non traumatica
Other intracranial haemorrhages
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10757 | 4015 | 6617 |
| Only index persons | 8357 | 3132 | 5225 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.12 | 0.18 |
| Only index persons | 0.17 | 0.12 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 74.17 | 76.06 | 73.01 |
| Only index persons | 73.90 | 75.44 | 72.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 981 | 306 | 675 |
| Unadjusted period prevalence (%) | 0.27 | 0.12 | 0.34 |
| Median age at first event (years) | 72.45 | 69.40 | 73.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_OTHINTRACRA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHINTRACRA | 2.148 [1.85, 2.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.346 |
During the follow-up period (1.1.1998 — 31.12.2019), 1445 out of 2816 females with I9_OTHINTRACRA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHINTRACRA | 2.024 [1.74, 2.35] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2569 out of 4843 males with I9_OTHINTRACRA died.
Mortality risk
Mortality risk for people of age
years, who have I9_OTHINTRACRA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.205% | 0.342% |
| 5 | 1.286% | 2.021% |
| 10 | 3.13% | 5.194% |
| 15 | 6.112% | 10.143% |
| 20 | 10.484% | 17.079% |
Relationships between endpoints
↥Index endpoint: I9_OTHINTRACRA – Other intracranial haemorrhages
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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