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Embolic stroke

Endpoint Browser PheWeb

I9_STR_EMBOLIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I63.1
  • Hospital discharge: ICD-9 — 4341A
  • Hospital discharge: ICD-8 — 43400|43499
  • Cause of death: ICD-10 — I63.1
  • Cause of death: ICD-9 — 4341A
  • Cause of death: ICD-8 — 43400|43499

2 out of 7 registries used, show all original rules.

1699

4. Check minimum number of events

None

1699

5. Include endpoints

None

1699

6. Filter based on genotype QC (FinnGen only)

1639

Control definitions (FinnGen only)

Control exclude I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28696 13054 14985
Only index persons 13155 5750 7405
Unadjusted period prevalence (%)
Whole population 0.40 0.37 0.42
Only index persons 0.25 0.21 0.28
Median age at first event (years)
Whole population 72.78 75.89 70.17
Only index persons 71.63 74.92 69.08

-FinnGen-

Key figures

All Female Male
Number of individuals 1639 523 1116
Unadjusted period prevalence (%) 0.45 0.21 0.56
Median age at first event (years) 70.10 70.11 70.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_STR_EMBOLIC and mortality.

Females

Parameter HR [95% CI] p-value
I9_STR_EMBOLIC 2.405 [2.14, 2.7] < 0.001
Birth year 0.995 [0.99, 1.0] 0.196

During the follow-up period (1.1.1998 — 31.12.2019), 2865 out of 4903 females with I9_STR_EMBOLIC died.

Males

Parameter HR [95% CI] p-value
I9_STR_EMBOLIC 1.916 [1.72, 2.13] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3377 out of 6534 males with I9_STR_EMBOLIC died.

Mortality risk

Mortality risk for people of age

years, who have I9_STR_EMBOLIC.

N-year risk Females Males
1 0.166% 0.377%
5 1.3% 1.977%
10 3.466% 4.817%
15 6.705% 9.438%
20 11.651% 15.913%

Relationships between endpoints

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Index endpoint: I9_STR_EMBOLIC – Embolic stroke

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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