No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
57655 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
880 |
6. Filter based on genotype QC (FinnGen only) |
847 |
Control definitions (FinnGen only)
Control conditions
not I9_AF
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Embolic stroke with flimmer
based on the number of shared cases.
Similar with more cases:
- Embolic stroke
- Ischaemic Stroke, excluding all haemorrhages
- Stroke, excluding SAH
- Stroke, including SAH
- Cerebrovascular diseases (FINNGEN)
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16896 | 8436 | 8086 |
| Only index persons | 7367 | 3543 | 3824 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.24 | 0.23 |
| Only index persons | 0.14 | 0.13 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 74.92 | 77.54 | 72.31 |
| Only index persons | 74.78 | 78.33 | 71.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 847 | 279 | 568 |
| Unadjusted period prevalence (%) | 0.23 | 0.11 | 0.29 |
| Median age at first event (years) | 72.48 | 74.10 | 71.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_STR_EMBOLIC_WITH_FLIMMER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC_WITH_FLIMMER | 2.272 [1.99, 2.59] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 1978 out of 3053 females with I9_STR_EMBOLIC_WITH_FLIMMER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC_WITH_FLIMMER | 1.913 [1.69, 2.17] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 1881 out of 3320 males with I9_STR_EMBOLIC_WITH_FLIMMER died.
Mortality risk
Mortality risk for people of age
years, who have I9_STR_EMBOLIC_WITH_FLIMMER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.212% | 0.392% |
| 5 | 1.238% | 2.458% |
| 10 | 3.16% | 6.167% |
| 15 | 6.259% | 11.018% |
| 20 | 10.935% | 18.91% |
Relationships between endpoints
↥Index endpoint: I9_STR_EMBOLIC_WITH_FLIMMER – Embolic stroke with flimmer
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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