congestive heart failure: Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
472380 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
33969 |
6. Filter based on genotype QC (FinnGen only) |
32733 |
Control definitions (FinnGen only)
Control exclude
I9_NONISCHCARDMYOP
Control conditions
not I9_HYPERTROCARDMYOP
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
All-cause Heart Failure
based on the number of shared cases.
Similar with more cases:
- Heart failure, strict
- Heart failure,strict
- Heart failure, not strict
- Other heart diseases
- Other heart diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 484404 | 256775 | 220183 |
| Only index persons | 302948 | 163636 | 139312 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.81 | 7.35 | 6.15 |
| Only index persons | 5.69 | 6.02 | 5.32 |
| Median age at first event (years) | |||
| Whole population | 73.77 | 75.78 | 71.55 |
| Only index persons | 74.97 | 77.41 | 72.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 32733 | 12285 | 20448 |
| Unadjusted period prevalence (%) | 8.23 | 4.82 | 10.27 |
| Median age at first event (years) | 71.30 | 71.77 | 71.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL_ALLCAUSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_ALLCAUSE | 1.756 [1.63, 1.89] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 92684 out of 147808 females with I9_HEARTFAIL_ALLCAUSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_ALLCAUSE | 2.309 [2.11, 2.53] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 81095 out of 132836 males with I9_HEARTFAIL_ALLCAUSE died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL_ALLCAUSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.308% |
| 5 | 0.676% | 1.881% |
| 10 | 1.772% | 5.011% |
| 15 | 3.342% | 9.27% |
| 20 | 5.681% | 15.096% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL_ALLCAUSE – All-cause Heart Failure
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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