cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
395335 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
12618 |
6. Filter based on genotype QC (FinnGen only) |
12164 |
Control definitions (FinnGen only)
Control conditions
not I9_IHD
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Non-ischemic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
- All-cause Heart Failure
- Heart failure, strict
- Heart failure,strict
- Heart failure, not strict
- Other heart diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 171885 | 97529 | 72268 |
| Only index persons | 120348 | 69873 | 50475 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.46 | 2.79 | 2.02 |
| Only index persons | 2.30 | 2.57 | 1.93 |
| Median age at first event (years) | |||
| Whole population | 74.13 | 76.58 | 70.92 |
| Only index persons | 74.71 | 77.56 | 70.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12164 | 5474 | 6690 |
| Unadjusted period prevalence (%) | 2.82 | 2.15 | 3.36 |
| Median age at first event (years) | 70.56 | 71.00 | 70.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_NONISCHCARDMYOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP | 1.723 [1.57, 1.89] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 32878 out of 61618 females with I9_NONISCHCARDMYOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP | 2.056 [1.83, 2.3] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 22829 out of 44906 males with I9_NONISCHCARDMYOP died.
Mortality risk
Mortality risk for people of age
years, who have I9_NONISCHCARDMYOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.332% |
| 5 | 0.753% | 2.137% |
| 10 | 2.033% | 5.388% |
| 15 | 3.927% | 9.819% |
| 20 | 6.897% | 16.234% |
Relationships between endpoints
↥Index endpoint: I9_NONISCHCARDMYOP – Non-ischemic cardiomyopathy
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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