nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1273 |
4. Check minimum number of eventsNone |
1273 |
5. Include endpointsNone |
1273 |
6. Filter based on genotype QC (FinnGen only) |
1217 |
Control definitions (FinnGen only)
Control exclude
I9_HYPERTENSION
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I10-I15
Name in latin
Morbus hypertensivus renalis
Similar endpoints
↥List of similar endpoints to
Hypertensive Renal Disease
based on the number of shared cases.
Similar with more cases:
- Hypertensive heart and/or renal disease
- Hypertension
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14004 | 5705 | 8046 |
| Only index persons | 9620 | 3999 | 5621 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.16 | 0.22 |
| Only index persons | 0.19 | 0.15 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 70.24 | 73.64 | 68.06 |
| Only index persons | 72.51 | 76.08 | 69.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1217 | 392 | 825 |
| Unadjusted period prevalence (%) | 0.33 | 0.15 | 0.41 |
| Median age at first event (years) | 67.46 | 64.88 | 68.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSRD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSRD | 2.586 [2.17, 3.08] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.155 |
During the follow-up period (1.1.1998 — 31.12.2019), 1318 out of 2344 females with I9_HYPTENSRD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSRD | 2.628 [2.25, 3.08] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 2041 out of 3952 males with I9_HYPTENSRD died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSRD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.294% | 0.514% |
| 5 | 1.466% | 3.231% |
| 10 | 3.662% | 7.2% |
| 15 | 6.979% | 13.563% |
| 20 | 12.004% | 21.28% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSRD – Hypertensive Renal Disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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