secondary hypertension: High blood pressure caused by an underlying medical condition.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3226 |
4. Check minimum number of eventsNone |
3226 |
5. Include endpointsNone |
3226 |
6. Filter based on genotype QC (FinnGen only) |
3089 |
Control definitions (FinnGen only)
Control exclude
FG_CVD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I10-I15
Name in latin
Hypertensio secundaria
Similar endpoints
↥List of similar endpoints to
Secondary hypertension
based on the number of shared cases.
Similar with more cases:
- Hypertension
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22516 | 10394 | 11903 |
| Only index persons | 18478 | 8734 | 9744 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.30 | 0.33 |
| Only index persons | 0.35 | 0.32 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 60.62 | 62.49 | 58.84 |
| Only index persons | 57.95 | 59.66 | 56.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3089 | 1335 | 1754 |
| Unadjusted period prevalence (%) | 0.73 | 0.52 | 0.88 |
| Median age at first event (years) | 56.56 | 54.77 | 57.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSEC | 2.374 [2.16, 2.61] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.243 |
During the follow-up period (1.1.1998 — 31.12.2019), 3157 out of 8812 females with I9_HYPTENSEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSEC | 2.532 [2.3, 2.79] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 3869 out of 10111 males with I9_HYPTENSEC died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.523% |
| 5 | 1.158% | 3.123% |
| 10 | 3.143% | 7.274% |
| 15 | 6.098% | 13.78% |
| 20 | 10.898% | 23.41% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSEC – Secondary hypertension
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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