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Pulmonary embolism

DOID EFO Endpoint Browser PheWeb

I9_PULMEMB

pulmonary embolism: The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I26
  • Hospital discharge: ICD-9 — 415
  • Hospital discharge: ICD-8 — 450
  • Cause of death: ICD-10 — I26
  • Cause of death: ICD-9 — 415
  • Cause of death: ICD-8 — 450

2 out of 7 registries used, show all original rules.

11661

4. Check minimum number of events

None

11661

5. Include endpoints

None

11661

6. Filter based on genotype QC (FinnGen only)

11269

Control definitions (FinnGen only)

Control exclude I9_PULMHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I26-I28
Name in latin Embolia pulmonalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 122590 66761 53967
Only index persons 82608 46099 36509
Unadjusted period prevalence (%)
Whole population 1.73 1.91 1.51
Only index persons 1.56 1.69 1.39
Median age at first event (years)
Whole population 70.01 71.92 67.63
Only index persons 68.28 70.19 65.87

-FinnGen-

Key figures

All Female Male
Number of individuals 11269 5714 5555
Unadjusted period prevalence (%) 2.51 2.24 2.79
Median age at first event (years) 65.50 64.28 66.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_PULMEMB and mortality.

Females

Parameter HR [95% CI] p-value
I9_PULMEMB 2.333 [2.13, 2.56] < 0.001
Birth year 0.994 [0.99, 1.0] 0.112

During the follow-up period (1.1.1998 — 31.12.2019), 17649 out of 37767 females with I9_PULMEMB died.

Males

Parameter HR [95% CI] p-value
I9_PULMEMB 2.632 [2.35, 2.95] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 13341 out of 29445 males with I9_PULMEMB died.

Mortality risk

Mortality risk for people of age

years, who have I9_PULMEMB.

N-year risk Females Males
1 0.178% 0.427%
5 1.197% 2.811%
10 3.159% 6.962%
15 5.964% 12.555%
20 10.197% 20.77%

Relationships between endpoints

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Index endpoint: I9_PULMEMB – Pulmonary embolism

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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